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There were no injuries sustained during the fire, which occurred at 7 Landscape Avenue.
The fire is suspected to have been caused by combustible material in proximity to a flue pipe in basement, officials said.
Approximately 50 Yonkers Fire Department personnel responded.
Chief Thomas Fitzpatrick, deputy chief of personnel, said the fire department's efforts were hampered by an oil truck on the street.
After firefighters opened the walls, it was determined there was some extension in damage to the upper floors.
According to fire officials, building department personnel are on the scene for evaluation.
Red Cross spokeswoman Carolyn Sherwin said the Red Cross relocated nine out of 12 people.
"They were able to get all of their things out, but we provided them with emergency relocation and food," she said.
Additionally, a puppy was rescued from the fire and is in stable condition.
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